Research Review

Long-Time Cannabis Use Associated With Psychosis

Young adults who have used cannabis or marijuana for a longer period of time appear more likely to have hallucinations or delusions or to meet criteria for psychosis, according to a report posted online in Archives of General Psychiatry.

Previous studies have identified an association between cannabis use and psychosis, according to background information in the article. However, concerns remain that this research has not adequately accounted for confounding variables.

John McGrath, MD, PhD, FRANZCP, of the Queensland Brain Institute of the University of Queensland in Australia, and colleagues studied 3,801 young adults born between 1981 and 1984. At a 21-year follow-up, when participants were an average age of 20.1, they were asked about cannabis use in recent years and assessed using several measures of psychotic outcomes (including a diagnostic interview, an inventory of delusions, and items identifying the presence of hallucinations).

At the 21-year follow-up, 17.7% reported using cannabis for three or fewer years, 16.2% for four to five years, and 14.3% for six or more years. Overall, 65 study participants received a diagnosis of nonaffective psychosis, such as schizophrenia, and 233 had at least one positive item for hallucination on the diagnostic interview.

Among all the participants, a longer duration since the first time they used cannabis was associated with multiple psychosis-related outcomes. “Compared with those who had never used cannabis, young adults who had six or more years since first use of cannabis (i.e., who commenced use when around 15 years or younger) were twice as likely to develop a nonaffective psychosis and were four times as likely to have high scores on the Peters et al Delusions Inventory [a measure of delusion],” the authors wrote. “There was a ‘dose-response’ relationship between the variables of interest: the longer the duration since first cannabis use, the higher the risk of psychosis-related outcomes.”

In addition, the researchers assessed the association between cannabis use and psychotic symptoms among a subgroup of 228 sibling pairs. The association persisted in this subgroup, “thus reducing the likelihood that the association was due to unmeasured shared genetic and/or environmental influences,” the authors continued.

“The nature of the relationship between psychosis and cannabis use is by no means simple,” they wrote. Individuals who had experienced hallucinations early in life were more likely to have used cannabis longer and to use it more frequently. “This demonstrates the complexity of the relationship: those individuals who were vulnerable to psychosis (i.e., those who had isolated psychotic symptoms) were more likely to commence cannabis use, which could then subsequently contribute to an increased risk of conversion to a nonaffective psychotic disorder.”