Research Review

Noninherited Genetic Factors Also in the Autism Mix

The largest and most rigorous twin study of its kind to date has found that shared environment influences susceptibility to autism more than previously thought.

The study found that shared environmental factors—experiences and exposures common to both twin individuals—accounted for 55% of strict autism and 58% of more broadly defined autism spectrum disorders (ASD). Genetic heritability accounted for 37% of autism and 38% of ASD. Random environmental factors not shared among twins play a much smaller role.

"High fraternal twin concordance relative to identical twin concordance underscores the importance of both the environment and moderate genetic heritability in predisposing for autism," explains Joachim Hallmayer, MD, of Stanford University in Palo Alto, Calif., a grantee of the National Institute of Mental Health. "Both types of twin pairs are more often concordant than what would be expected from the frequency of autism in the general population. However, the high concordance among individuals who share only half their genes relative to those who share all of their genes implies a bigger role for shared environmental factors."

Hallmayer, senior coinvestigator Neil Risch, PhD, of the University of California, San Francisco, and colleagues report on findings of the California Autism Twins Study (CATS) in the Archives of General Psychiatry.

The new study is the first to analyze a large sample of twins drawn from the general population; previous twin studies have been based on more limited samples, such as patients in treatment. It is also the first to employ the latest standard in diagnosing autism, which requires structured clinical assessments based on interviews with the parents as well as direct observation of the child.

Drawing upon state records, the researchers initially identified 1,156 twin pairs, with at least one member affected by an ASD, born to California mothers between 1987 and 2004. The children were all at least 4 years old, an age when autism can be reliably diagnosed. Ultimately, this group was winnowed to 192 twin pairs—54 identical and 138 fraternal—for genetic analysis. Since autism disproportionately affects males, males outnumbered females by four to five times, with 80 of the pairs including both sexes.

Concordance for ASD was 77% among identical male pairs, and 31% among fraternal male pairs. In females, concordance for ASD was more closely spaced—50% for identical and 36% for fraternal pairs. By contrast, previous studies had found concordance rates for fraternal twins that were much lower, ranging only in the single digits.

"Spectrum disorders traditionally thought to have less genetic loading turn out to stem from a similar mix of environmental and genetic heritability as narrowly defined autism," notes Thomas Lehner, PhD, chief of the NIMH Genomics Research Branch.

Yet, there can also be genetic influences that are not inherited from parents. New evidence emerged last month that rare, spontaneous mutations occur at abnormally high rates in autism.

"Such non-inherited genetic changes were proposed as a major mechanism of autism susceptibility, based on the very low concordance among fraternal twins found in earlier studies and evidence of increased risk associated with older parental age," explains Risch. "In light of the high fraternal twin concordance observed in our study, such new mutations may play a more limited role, since they would primarily occur in only one member of a fraternal pair, which would not lead to concordance."

— Source: National Institute of Mental Health